SUPARTZ

SUPARTZ is a sterile solution:
- Non-pyrogenic sodium hyaluronate, highly purified, free of inflammatory action.
- With a high molecular weight that is extracted from cockscombs.
- Transparent and odourless.
- Sodium hyaluronate of bacterial origin derived by fermentation and purification.

- NEOPHARMED GENTILI S.P.A.
- NAME: SUPARTZ
- COMPOSITION: 2.5 ml 1% sodium hyaluronate solution.
- PRESENTATION: 5 x 2.5 ml.
- NEEDLE: Use a 22-23G needle.
- INDICATIONS: SUPARTZ is indicated for the treatment of and periarthritis of the shoulder, with the aim of improving joint mobility and reducing pain.
- INJECTION DEPTH: The dosage is 2.5 mL per knee joint injected intra-articularly or into the shoulder joint (shoulder joint socket, subacromial bursa or long head tendon sheath of the biceps brachii). Use an aseptic injection technique.
- DURATION: The recommended treatment regimen for SUPARTZ in adults consists of five injections into the knee socket or shoulder joint, at intervals of one per week. However, the injection timing may be modified according to the patient's symptoms.
- USE: Strict medical use.

- Syringes: 5 x 2.5 ml.

Knee and shoulder.

2.5 ml of 1% sodium hyaluronate solution.

- Prior to injection, it is advisable to aspirate any excess fluid to ensure proper intra-articular administration.
- Use aseptic technique to avoid local complications.
- Avoid using disinfectants containing quaternary ammonium salts in skin preparation, as they can cause precipitation of the product.
- Inform the patient to avoid intense physical activity or prolonged loading on the treated joint for at least 48 hours after the injection.
- Use with caution in patients with severe joint inflammation, coagulopathy, or hepatic/venous insufficiency.
- Store the product below 25 °C, do not freeze.

SUPARTZ is contraindicated in the following cases:
- Do not administer SUPARTZ to patients with known hypersensitivity to the components of the formulation or to other sodium hyaluronate preparations.
- Do not use in the presence of active joint infection or infection of the skin overlying the injection site.
- Do not use in patients with hypersensitivity to proteins of avian origin or suspected allergies to such proteins.
- Use is not recommended in children or during pregnancy and lactation.

SUPARTZ protects and coats the surfaces of deteriorated cartilage by diffusing into its matrix. It prevents the detachment of proteoglycans and reduces degenerative changes in cartilage. It also acts on tendons, preventing adhesion to the sheath and improving joint movement through a physical barrier. It improves the lubricating function of synovial fluid by increasing the viscosity and molecular weight of pathological hyaluronic acid, and helps reduce the action of pain mediators by coating intra-articular tissues.